Skepta and David Bowie are among the stars expected to win at the Brit Awards on Wednesday night. The grime star and the late rock icon are up for best British male. Other nominees at “music’s biggest night” include Beyonce, The 1975 and Bastille.

Performances will come from Ed Sheeran and Little Mix, as well as US stars Katy Perry and Bruno Mars. Dermot O’Leary and Emma Willis have been drafted in to present the ceremony at London’s O2 Arena, after original host Michael Buble pulled out to care for his young son, who is receiving treatment for cancer.

“Every part of me sends so much love and all the best wishes in the world to Michael and his family at such a difficult time,” she said.

This year’s ceremony is notable for its recognition of grime, which re-emerged from the underground last year, asserting its position as the UK’s biggest musical movement since Britpop. Skepta, who won the 2016 Mercury Prize for his self-released album Konnichiwa, is favourite to win best breakthrough artist; while fellow grime MCs Stormzy and Kano are also up for awards.

Bowie—who died in January last year—is likely to prevail in the best British male category, as the music industry takes its chance to honour one of rock’s most recognisable and influential figures. His haunting swansong, Blackstar, is also up for best British album. Pop group Little Mix tie with Skepta for the most-nominated act of the night— each has three. But the girl band look like they will be locked out of their categories, best group (likely to go to The 1975), best video (One Direction) and best single (Clean Bandit, for Rockabye).

Meanwhile, Beyonce and her younger sister Solange Knowles are both up for best international female, after releasing albums about race and politics last year.